According to reports, a booster shot of an inhalable COVID-19 vaccine created by China’s CanSino Biologics resulted in a 250- to 300-fold increase in neutralising antibody levels.
The aerosolised inhaled adenovirus Type-5 vector-based COVID-19 vaccine (Ad5-nCoV), taken after two doses of inactivated vaccine shots for half a year, has been proven to be safe and significantly more immunogenic than taking an inactivated vaccine as a booster, according to recent lab studies by the Chinese drug maker, according to the Global Times.
Taking an inactivated vaccine as a booster after two inactivated vaccine shots, on the other hand, only raises neutralising antibodies by 30 times, according to the study.
According to the paper, a heterologous (mix-match vaccination regimen) prime-boost regimen is more likely than a homogeneous (same vaccine regimen) booster dose to increase the breadth, intensity, and persistence of the immune response.
Zhu Tao, co-founder and chief scientific officer of CanSinoBIO, cited a previous study conducted in Turkey that found that a booster dose of the mRNA vaccine commonly used in Western countries for people administered along with two inactivated doses can increase neutralising antibodies by about 25 times when compared to a booster dose of the inactivated vaccine alone.
A heterologous booster dose regimen with three licenced vaccinations — one adenovirus-based vaccine by Johnson & Johnson and two mRNA vaccines by Moderna and Pfizer — was tested in a similar clinical trial by US researchers. The findings revealed that a heterologous regimen boosts immunity.
According to a study published recently on the pre-print server medRvix, homologous boosters boosted neutralising antibody titers by 4.2 to 20-fold, while heterologous boosters increased titers by 6.2 to 76-fold.
At least 13 Chinese provinces and regions, including East China’s Anhui and Fujian provinces, and Central China’s Hubei Province, have launched programmes to boost inhabitants’ immunity to COVID-19, according to the article.
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